ea0032p70 | Bone and Osteoporosis | ECE2013
Kvist Torben
, Petersen Solveig
, Frederiksen Anja
, Syberg Susanne
, Jorgensen Niklas
, Schwarz Peter
Bone loss in chronic autoimmune inflammatory diseases is a major clinical problem. Inflammation-mediated osteoposis (IMO) is the first animal model of generalized osteoporosis resulting from inflammation. The P2×7 receptor, an ATP-gated ion-channel, is primarily expressed on immune and bone cells. ATP is now seen as a novel inflammatory mediator, with P2×7 as main target of the pro-inflammatory activity. The P2×7-receptor has a regulatory role in bone formation ...